Effect of 150 kHz electromagnetic radiation on the development of polycystic ovaries induced by estradiol Valerate in Sprague Dawley rats

Abstract Background Polycystic ovary syndrome (PCOS) is the most common complex endocrine disorder affecting approximately 2–20% of reproductive aged females. Tumour Treating Fields (100–300 kHz) a recent innovative, non-invasive therapeutic approach to cancer therapy. This frequency as an alternative therapy for management polycystic ovaries has not yet been explored. Objectives To explore effect full-body exposure 150 kHz Electromagnetic Radiation (EMR), on development in estradiol valerate-induced PCO rat model. Method Twenty-one female adult rats were divided into three groups ( n = 7 each): control, Estradiol Valerate (EV) and EV + EMR groups. The group was subjected full body at continuously eight consecutive weeks. valerate administered orally induce Body ovarian weights recorded analysed. regularity estrous cycle assessed all histological study tissue carried out by haematoxylin eosin staining. serum concentration levels Luteinizing Hormone (LH), Follicle-Stimulating (FSH) testosterone measured using ELISA method. Results did differ significantly between found be irregular both Ovarian histology revealed near normal morphology with little or no degenerative morphological changes developing follicles exposed group. Histometrical analysis showed increased number significant reduction size follicular cysts p < 0.05) Hormonal difference FSH However, LH, LH/FSH ratio decreased compares Conclusion appear have follicles, typical 0.05).